MS Society of Canada Research News

MS Society of Canada Research News http://www.mssociety.ca/en/research/researchlibrary.htm News in Research Wed, 24 June 2009 11:23:00 EST en-can Results of Phase II "CHOICE" Study Published, Showing that Daclizumab Reduced Disease Activity in Relapsing MS, and Revealing Novel Immune Mechanism http://www.mssociety.ca/en/research/medmmo_20100304.htm http://www.mssociety.ca/en/research/medmmo_20100304.htm 4 Mar 2010 9:05:00 EST Clinical effect of neutralizing antibodies to interferon beta that persist long after cessation of therapy for multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20100303.htm http://www.mssociety.ca/en/research/medmmo_20100303.htm 3 Mar 2010 11:15:00 EST MRI of the corpus callosum in multiple sclerosis: association with disability http://www.mssociety.ca/en/research/medmmo_20100303_corpus.htm http://www.mssociety.ca/en/research/medmmo_20100303_corpus.htm 3 Mar 2010 11:15:00 EST Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene http://www.mssociety.ca/en/research/medmmo_20100303_STAT3.htm http://www.mssociety.ca/en/research/medmmo_20100303_STAT3.htm 3 Mar 2010 11:15:00 EST Atorvastatin Combined To Interferon to Verify the Efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy http://www.mssociety.ca/en/research/medmmo_20100301.htm http://www.mssociety.ca/en/research/medmmo_20100301.htm 1 Mar 2010 15:45:00 EST High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20100216.htm http://www.mssociety.ca/en/research/medmmo_20100216.htm 16 Feb 2010 10:30:00 EST The rising prevalence and changing age distribution of multiple sclerosis in Manitoba http://www.mssociety.ca/en/research/medmmo_20100202.htm http://www.mssociety.ca/en/research/medmmo_20100202.htm 2 Feb 2010 13:00:00 EST Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial http://www.mssociety.ca/en/research/medmmo_20100129FAM.htm http://www.mssociety.ca/en/research/medmmo_20100129FAM.htm 29 Jan 2010 15:40:00 EST Interferon-gamma-producing T cells, pregnancy, and postpartum relapses of multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20100129.htm http://www.mssociety.ca/en/research/medmmo_20100129.htm 29 Jan 2010 10:45:00 EST Results Published from Phase 3 Study of Oral Cladribine in Relapsing-Remitting MS http://www.mssociety.ca/en/research/medmmo_20100128.htm http://www.mssociety.ca/en/research/medmmo_20100128.htm 28 Jan 2010 11:30:00 EST Positive Results Published on Clinical Trials of Oral FTY720 (Fingolimod) for Relapsing MS - Novartis Applies to FDA and European Regulatory Agency for Approval http://www.mssociety.ca/en/research/medmmo_20100127.htm http://www.mssociety.ca/en/research/medmmo_20100127.htm 27 Jan 2010 14:30:00 EST Regional brain atrophy in primary fatigued patients with multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20100126.htm http://www.mssociety.ca/en/research/medmmo_20100126.htm 26 Jan 2010 11:30:00 EST No Effect of Parental Age on Risk of Multiple Sclerosis: A Population-Based Study http://www.mssociety.ca/en/research/medmmo_20100121.htm http://www.mssociety.ca/en/research/medmmo_20100121.htm 21 Jan 2010 14:45:00 EST Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results http://www.mssociety.ca/en/research/medmmo_20100112.htm http://www.mssociety.ca/en/research/medmmo_20100112.htm 12 Jan 2010 16:15:00 EST A randomized trial of memantine as treatment for spasticity in multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20100111.htm http://www.mssociety.ca/en/research/medmmo_20100111.htm 11 Jan 2010 10:05:00 EST HLA-DRB1 and month of birth in multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20100108.htm http://www.mssociety.ca/en/research/medmmo_20100108.htm 8 Jan 2010 12:25:00 EST Callosal lesion predicts future attacks after clinically isolated syndrome http://www.mssociety.ca/en/research/medmmo_20100104.htm http://www.mssociety.ca/en/research/medmmo_20100104.htm 4 Jan 2010 11:15:00 EST A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS http://www.mssociety.ca/en/research/medmmo_20100104_MRI.htm http://www.mssociety.ca/en/research/medmmo_20100104_MRI.htm 4 Jan 2010 11:15:00 EST Positive Results Announced in Phase II Study of IV Ocrelizumab in Relapsing-Remitting MS http://www.mssociety.ca/en/research/medmmo_20091210.htm http://www.mssociety.ca/en/research/medmmo_20091210.htm 10 Dec 2009 10:55:00 EST Body size and risk of MS in two cohorts of US women http://www.mssociety.ca/en/research/medmmo_20091124.htm http://www.mssociety.ca/en/research/medmmo_20091124.htm 24 Nov 2009 13:15:00 EST Chronic cerebrospinal venous insufficiency (CCSVI) and MS http://www.mssociety.ca/en/research/medmmo_20091021_faq.htm http://www.mssociety.ca/en/research/medmmo_20091021_faq.htm 21 Nov 2009 10:30:00 EST Impact of Multiple Sclerosis Relapses on Progression Diminishes with time http://www.mssociety.ca/en/research/medmmo_20091118.htm http://www.mssociety.ca/en/research/medmmo_20091118.htm 18 Nov 2009 10:30:00 EST Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial http://www.mssociety.ca/en/research/medmmo_20091109.htm http://www.mssociety.ca/en/research/medmmo_20091109.htm 9 Nov 2009 15:30:00 EST Efficacy and specificity of intensive cognitive rehabilitation of attention and executive functions in multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20091027.htm http://www.mssociety.ca/en/research/medmmo_20091027.htm 27 Oct 2009 11:15:00 EST Consideration of the risk of secondary leukemia after mitoxantrone in multiple sclerosis populations is required http://www.mssociety.ca/en/research/medmmo_20091027mito.htm http://www.mssociety.ca/en/research/medmmo_20091027mito.htm 27 Oct 2009 11:15:00 EST Research into Blood Flow in the Brain and Venous Insufficiency, or CCSVI, in MS http://www.mssociety.ca/en/research/medmmo_20091021.htm http://www.mssociety.ca/en/research/medmmo_20091021.htm 21 Oct 2009 14:30:00 EST Two reports for Management of Trigeminal Neuralgia in Multiple Sclerosis http://www.mssociety.ca/en/research/medmmo_20091020.htm http://www.mssociety.ca/en/research/medmmo_20091020.htm 20 Oct 2009 12:45:00 EST PreCISe Study Results – Showing Benefit of Copaxone® in People at High Risk for MS http://www.mssociety.ca/en/research/medmmo_20091020precise.htm http://www.mssociety.ca/en/research/medmmo_20091020precise.htm 20 Oct 2009 12:45:00 EST Therapeutic Strategies for MS and More Highlighted at ECTRIMS Conference http://www.mssociety.ca/en/research/medmmo_20091015.htm http://www.mssociety.ca/en/research/medmmo_20091015.htm 15 Oct 2009 14:15:00 EST Preliminary work suggests that minocycline as add-on therapy may offer improved efficacy of glatiramer acetate in relapsing-remitting multiple sclerosis . Authors suggest further research needed. http://www.mssociety.ca/en/research/medmmo_20091013.htm http://www.mssociety.ca/en/research/medmmo_20091013.htm 13 Oct 2009 10:45:00 EST 250 mug or 500 mug interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study http://www.mssociety.ca/en/research/medmmo_20090922.htm http://www.mssociety.ca/en/research/medmmo_20090922.htm 22 Sept 2009 10:45:00 EST Asymptomatic reactivation of JC virus in patients treated with natalizumab http://www.mssociety.ca/en/research/medmmo_20090922JC.htm http://www.mssociety.ca/en/research/medmmo_20090922JC.htm 22 Sept 2009 10:45:00 EST Correlation between disability and transcranial magnetic stimulation abnormalities in patients with multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090910.htm http://www.mssociety.ca/en/research/medmmo_20090910.htm 10 Sept 2009 15:30:00 EST Effect of immigration on multiple sclerosis female to male ratio in Canada: the Canadian Collaborative Study http://www.mssociety.ca/en/research/medmmo_20090909.htm http://www.mssociety.ca/en/research/medmmo_20090909.htm 9 Sept 2009 13:00:00 EST Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090903_mri.htm http://www.mssociety.ca/en/research/medmmo_20090903_mri.htm 3 Sept 2009 13:30:00 EST Gestational diabetes and multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090903.htm http://www.mssociety.ca/en/research/medmmo_20090903.htm 3 Sept 2009 11:30:00 EST Care Given to People with MS by Family Members Presents Unique Challenges - Study funded by National MS Society points to need for respite and mental health support for family care givers http://www.mssociety.ca/en/research/medmmo_20090902.htm http://www.mssociety.ca/en/research/medmmo_20090902.htm 2 Sept 2009 09:30:00 EST Sponsor Reports Positive Results of Clinical Trial of Zenvia™ for Pseudobulbar Affect (Uncontrollable Laughing and/or Crying) http://www.mssociety.ca/en/research/medmmo_20090831.htm http://www.mssociety.ca/en/research/medmmo_20090831.htm 31 Aug 2009 13:15:00 EST Pilot study of a cognitive intervention program for persons with multiple sclerosis. http://www.mssociety.ca/en/research/medmmo_20090818.htm http://www.mssociety.ca/en/research/medmmo_20090818.htm 18 Aug 2009 10:00:00 EST The impact of physical activity on fatigue, depression and quality of life in persons with multiple sclerosis. http://www.mssociety.ca/en/research/medmmo_20090730.htm http://www.mssociety.ca/en/research/medmmo_20090730.htm 30 Jul 2009 15:45:00 EST Dirucotide Does Not Meet Primary Endpoint in Phase III MAESTRO-01 Trial In Secondary Progressive Multiple Sclerosis http://www.mssociety.ca/en/research/medmmo_20090729.htm http://www.mssociety.ca/en/research/medmmo_20090729.htm 29 Jul 2009 14:45:00 EST Study Adds Evidence that Smoking Worsens MS, and Quitting May Help http://www.mssociety.ca/en/research/medmmo_20090728.htm http://www.mssociety.ca/en/research/medmmo_20090728.htm 28 Jul 2009 09:45:00 EST "Benign” Course of MS Evaluated with MRI and Other Imaging Methods by European Collaborators http://www.mssociety.ca/en/research/medmmo_20090722.htm http://www.mssociety.ca/en/research/medmmo_20090722.htm 22 Jul 2009 13:00:00 EST Parent-of-origin effect in multiple sclerosis. Observations from interracial matings http://www.mssociety.ca/en/research/medmmo_20090706parent.htm http://www.mssociety.ca/en/research/medmmo_20090706parent.htm 6 Jul 2009 11:00:00 EST Age of onset in concordant twins and other relative pairs with multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090706twins.htm http://www.mssociety.ca/en/research/medmmo_20090706twins.htm 6 Jul 2009 11:00:00 EST Two Studies Report Finding New Genes and Gene Regions that Make People Susceptible to MS http://www.mssociety.ca/en/research/medmmo_20090706.htm http://www.mssociety.ca/en/research/medmmo_20090706.htm 6 Jul 2009 11:00:00 EST Assessing the clinical efficacy of sildenafil for the treatment of female sexual dysfunction http://www.mssociety.ca/en/research/medmmo_20090629.htm http://www.mssociety.ca/en/research/medmmo_20090629.htm 29 Jun 2009 10:00:00 EST Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a http://www.mssociety.ca/en/research/medmmo_20090629stat.htm http://www.mssociety.ca/en/research/medmmo_20090629stat.htm 29 Jun 2009 10:00:00 EST Two Medical Meetings (ACTRIMS and CMSC) Focus on MS Risk Factors and Quality of Life Issues http://www.mssociety.ca/en/research/medmmo_20090624.htm http://www.mssociety.ca/en/research/medmmo_20090624.htm 24 Jun 2009 11:05:00 EST Remyelination capacity of the MS brain decreases with disease chronicity http://www.mssociety.ca/en/research/medmmo_20090623.htm http://www.mssociety.ca/en/research/medmmo_20090623.htm 23 Jun 2009 11:05:00 EST Efficacy of intramuscular interferon beta-1a in patients with clinically isolated syndrome: analysis of subgroups based on new risk criteria http://www.mssociety.ca/en/research/medmmo_20090617.htm http://www.mssociety.ca/en/research/medmmo_20090617.htm Jun 17 1:50:00 EST Randomized Clinical Trial of Balance-Based Torso Weighting for Improving Upright Mobility in People with Multiple Sclerosis http://www.mssociety.ca/en/research/medmmo_20090615.htm http://www.mssociety.ca/en/research/medmmo_20090615.htm Jun 15 2:15:00 EST Report of American Academy of Neurology Meeting Seattle April 2009 http://www.mssociety.ca/en/research/medmmo_20090609.htm http://www.mssociety.ca/en/research/medmmo_20090609.htm Jun 9 15:30:00 EST Parity and secondary progression in multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090608.htm http://www.mssociety.ca/en/research/medmmo_20090608.htm Jun 8 10:00:00 EST Update on oral therapies for MS reported at the American Academy of Neurology Meeting http://www.mssociety.ca/en/research/medmmo_20090526.htm http://www.mssociety.ca/en/research/medmmo_20090526.htm 26 May 2009 10:00:00 EST Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease http://www.mssociety.ca/en/research/medmmo_20090519.htm http://www.mssociety.ca/en/research/medmmo_20090519.htm 19 May 2009 10:39:00 EST The relationship between handedness and risk of multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090514.htm http://www.mssociety.ca/en/research/medmmo_20090514.htm 14 May 2009 10:30:00 EST Multiple Sclerosis and Academic Work: Socio-Spatial Strategies Adopted to Maintain Employment http://www.mssociety.ca/en/research/medmmo_20090511.htm http://www.mssociety.ca/en/research/medmmo_20090511.htm 11 May 2009 11:30:00 EST The clinical and urodynamic results of a 3-month percutaneous posterior tibial nerve stimulation treatment in patients with multiple sclerosisrelated neurogenic bladder dysfunction http://www.mssociety.ca/en/research/medmmo_20090504.htm http://www.mssociety.ca/en/research/medmmo_20090504.htm 04 May 2009 10:30:00 EST Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: a diffusion tensor imaging study at 3T http://www.mssociety.ca/en/research/medmmo_20090430.htm http://www.mssociety.ca/en/research/medmmo_20090430.htm 30 Apr 2009 14:30:00 EST The search for responsive clinical endpoints in primary progressive multiple sclerosis http://www.mssociety.ca/en/research/medmmo_20090430ppms.htm http://www.mssociety.ca/en/research/medmmo_20090430ppms.htm 30 Apr 2009 14:30:00 EST Prevalence and impact of pain in multiple sclerosis: physical and psychologic contributors http://www.mssociety.ca/en/research/medmmo_20090420.htm http://www.mssociety.ca/en/research/medmmo_20090420.htm 20 Apr 2009 11:30:00 EST Pain and quality of life in the early stages after multiple sclerosis diagnosis: a 2-year longitudinal study http://www.mssociety.ca/en/research/medmmo_20090414.htm http://www.mssociety.ca/en/research/medmmo_20090414.htm 14 Apr 2009 10:00:00 EST Efficacy of treatment of MS with IFN{beta}-1b or glatiramer acetate by monthly brain MRI in the BECOME study http://www.mssociety.ca/en/research/medmmo_20090325.htm http://www.mssociety.ca/en/research/medmmo_20090325.htm 25 Mar 2009 10:30:00 EST Studies Reported: Function, Combination Drug Therapy, Cognition, and Causation http://www.mssociety.ca/en/research/medmmo_20090318.htm http://www.mssociety.ca/en/research/medmmo_20090318.htm 18 Mar 2009 15:30:00 EST Genetics Studies Yield New Clues to Why People Get MS http://www.mssociety.ca/en/research/medmmo_20090317.htm http://www.mssociety.ca/en/research/medmmo_20090317.htm 17 Mar 2009 09:00:00 EST New Studies Bolster Possible Link Between Epstein-Barr Virus and MS http://www.mssociety.ca/en/research/medmmo_20090316.htm http://www.mssociety.ca/en/research/medmmo_20090316.htm 16 Mar 2009 14:30:00 EST Predicting accidental falls in people with multiple sclerosis -- a longitudinal study http://www.mssociety.ca/en/research/medmmo_20090306.htm http://www.mssociety.ca/en/research/medmmo_20090306.htm 06 Mar 2009 11:00:00 EST Young Smokers Increase Risk for Multiple Sclerosis http://www.mssociety.ca/en/research/medmmo_20090303.htm http://www.mssociety.ca/en/research/medmmo_20090303.htm 03 Mar 2009 11:00:00 EST Breastfeeding may have an impact on reducing Multiple Sclerosis Relapses http://www.mssociety.ca/en/research/medmmo_20090303bf.htm http://www.mssociety.ca/en/research/medmmo_20090303bf.htm 03 Mar 2009 11:00:00 EST Results of the Avonex Combination Trial (ACT) in relapsing-remittng MS http://www.mssociety.ca/en/research/medmmo_20090223.htm http://www.mssociety.ca/en/research/medmmo_20090223.htm 23 Feb 2009 03:00:00 EST Incidence of acquired demyelination of the central nervous system in Canadian children http://www.mssociety.ca/en/research/medmmo_20090211.htm http://www.mssociety.ca/en/research/medmmo_20090211.htm 11 Feb 2009 09:00:00 EST Researchers Report Good Results from Small Study of Stem Cell Therapy to “Reboot” Immune System in MS http://www.mssociety.ca/en/research/medmmo_20090209.htm http://www.mssociety.ca/en/research/medmmo_20090209.htm 09 Feb 2009 14:00:00 EST Genetic study supports vitamin D deficiency as an environmental factor in MS susceptibility http://www.mssociety.ca/en/research/medmmo_20090205.htm http://www.mssociety.ca/en/research/medmmo_20090205.htm 05 Feb 2009 11:00:00 EST Oral Cladribine Reduces MS Relapses in Phase 3 Clinical Trial http://www.mssociety.ca/en/research/medmmo_20090128.htm http://www.mssociety.ca/en/research/medmmo_20090128.htm 28 Jan 2009 10:00:00 EST Restless Leg Syndrome in multiple sclerosis:A case-control study http://www.mssociety.ca/en/research/medmmo_20090115.htm http://www.mssociety.ca/en/research/medmmo_20090115.htm 15 Jan 2009 10:00:00 EST Physical activity and quality of life in multiple sclerosis: intermediary roles of disability, fatigue, mood, pain, self-efficacy and social support http://www.mssociety.ca/en/research/medmmo_20090108.htm http://www.mssociety.ca/en/research/medmmo_20090108.htm 8 Jan 2009 15:00:00 EST Oral FTY720 (Fingolimod) Reduced Relapse Rate More Effectively Than Avonex in Initial Results of One-Year Study in Relapsing-Remitting MS http://www.mssociety.ca/en/research/medmmo_20090105fty.htm http://www.mssociety.ca/en/research/medmmo_20090105fty.htm 5 Jan 2009 15:00:00 EST Dr. Brenda Banwell, a well known Canadian pediatric researcher, is an author on 2 papers about the use of MRI in children with MS, published in Neurology. 2006 Nov 26 (Epub ahead of print) http://www.mssociety.ca/en/research/medmmo_20090105.htm http://www.mssociety.ca/en/research/medmmo_20090105.htm 5 Jan 2009 15:00:00 EST